文章摘要
苏帆1,2,张宁峰1,刘有静1,邓桢翰2,许鉴2,陈康2,朱伟民1,2.全关节镜下基质诱导的自体软骨细胞移植 修复膝软骨缺损[J].,2019,27(17):1605-1608
全关节镜下基质诱导的自体软骨细胞移植 修复膝软骨缺损
All-arthroscopic implantation of matrix-induced autologous chondrocytes for knee cartilage defects
投稿时间:2019-06-28  
DOI:
中文关键词: 软骨缺损, 全关节镜技术, 自体细胞软骨移植
英文关键词: cartilage defect, all-arthroscopic technique, autologous chondrocyte cartilage implantation
基金项目:
作者单位
苏帆1,2  
张宁峰1  
刘有静1  
邓桢翰2  
许鉴2  
陈康2  
朱伟民1,2  
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中文摘要:
      摘要:[目的] 介绍全关节镜下自体软骨细胞移植修复膝软骨缺损的技术及疗效。[方法] 选取 2016 年 8 月~ 2018 年 8 月,共有 22 例膝软骨缺损患者,初次手术取患膝非负重区软骨体外培养、扩增并与胶原纤维支架复合,3 周后接受自体软骨细胞移植,全程均在关节镜下进行。术后 3、6、12 个月随访。[结果] 所有患者手术顺利,无严 重并发症发生。与术前相比较,术后 12 个月 VAS 评分显著降低[(5.36±0.95)vs(0.32±0.48),P<0.001],Lysholm 评分显著增加 [(59.18±4.92) vs (90.64±1.84),P<0.001]。术后 12 个月 T2 Mapping 核磁 Z 值较术初显著改善 [(0.42±0.06) vs (0.89±0.08),P<0.001]。[结论] 全关节镜下自体软骨细胞移植修复膝关节缺损可以迅速改善症 状,无严重并发症。
英文摘要:
      Abstract: [Objective] To introduce the surgical technique and clinical outcomes of matrix-induced autologous chondro? cytes implantation under arthroscopy for knee cartilage defects. [Methods] A total of 22 patients diagnosed with knee cartilage defects from August 2016 to August 2018 were treated with all-arthroscopic matrix-induced autologous implantation (MACI) . The Lysholm score, VAS score and T2 value depending on T2 Mapping MRI were used for assessment of the clinical conse? quences. [Results] All patients had operation conducted successfully without serious complications. Compared with those preop? eratively, the VAS score significantly decreased [(5.36±0.95) vs (0.32±0.48) , P<0.001] , while the Lysholm score significantly increased at 12 months postoperatively [(59.18±4.92) vs (90.64±1.84) , P<0.001] . In addition, the T2 mapping MRI Z value sig? nificantly improved compared the data immediately after operation with that at 12 months postoperatively [(0.42±0.06) vs (0.89± 0.08) , P<0.001] . [Conclusion] This matrix-induced autogenous chondrocyte implantation under all-arthroscopy does effective? ly improve the symptoms of knee cartilage defects without serious complications.
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