文章摘要
路凡,何良志,滕飞,耿彬,李睿,张小辉,赵良功,夏亚一.MALAT1 参与骨肉瘤发生发展机制的研究进展[J].,2019,27(17):1574-1578
MALAT1 参与骨肉瘤发生发展机制的研究进展
Research advances in mechanism of MALAT1 involved in the development of osteosarcoma
投稿时间:2019-04-06  
DOI:
中文关键词: 
英文关键词: 
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作者单位
路凡  
何良志  
滕飞  
耿彬  
李睿  
张小辉  
赵良功  
夏亚一  
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中文摘要:
      摘要:肺腺癌转移相关转录本 1 (metastasis associated lung adenocarcinoma transcript 1, MALAT1) 是长链非编码 RNA (long noncoding RNA, lncRNA) 的一种,其参与骨肉瘤 (osteosarcoma, OS) 发生发展的机制十分复杂,可通过 与 miRNA 作用等方式促进骨肉瘤细胞的增殖,可通过上调细胞周期蛋白依赖性激酶 9 (cyclin-dependent kinase 9, CDK9)的水平等途径抑制骨肉瘤细胞的凋亡,也可通过促进转化生长因子 A(transforming growth factor A, TGFA)的 表达等方式介导骨肉瘤细胞的侵袭转移。总之,MALAT1 可通过多种作用机制参与到骨肉瘤细胞的进展过程中,本 文拟对 MALAT1 在骨肉瘤细胞增殖、凋亡和侵袭转移过程中的分子作用机制进行综述。
英文摘要:
      Abstract: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) , a kind of long noncoding RNA, involves in the occurrence and development of osteosarcoma, however, its mechanism is very complex. The MALAT1 can promote prolifera? tion of osteosarcoma cells by interaction with miRNA and other means, and also exert impact on upregulation of the level of CDK9 or other ways to inhibit the apoptosis of osteosarcoma cells. Moreover, the MALAT1 mainly increase the expression of TG? FA to mediate the invasion and metastasis of osteosarcoma cells. In brief the MALAT1 participates in the progression of osteo? sarcoma cells through a variety of mechanisms. This paper aims to review the molecular mechanism of MALAT1 in the proliferation, apoptosis, invasion and metastasis of osteosar? coma cells.
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