Bone defects are often caused by high-energy injury, open injury combined with infection, primary and secondary bone tu-mors, surgical debridement of osteomyelitis, and congenital skeletal dysplasia. With the progress of human society and the continuous im-provement of people's living standards, the number of patients with complex open fracture of the lower leg is also increasing year by year.Due to the special anatomical position and characteristics of the tibia and fibula, traumatic and open comminuted fractures lead to bone de-fects of the tibia and fibula, which account for a large proportion of bone defects. However, the traditional treatment for complex open tibiaand fibula fractures is strict debridement and fracture reduction in the first stage, and bone grafting and internal or external fixation in thesecond stage. Due to heavy wound contamination and soft tissue defect, it is prone to be infectious bone defect in the later stage. At present,there are many treatment methods for infected tibiofibular bone defects, but each technique has advantages and disadvantages. This articleaims to review the current research status of treatment of infected tibiofibular bone defects at home and abroad, so as to provide a necessaryreference for clinicians to handle the infected tibiofibular bone defects in the proper ways, which is beneficial to the patients to the greatestextent and reduce the pain of patients.