Blood vessels in bone tissue play an important role in bone growth, development, remodeling and injury repair. Type H ves-sels are a subtype of bone vessels with high expression of CD31 and Emcn, which have significant anatomical characteristics and age-de-pendent decline characteristics, and are deeply involved in the coupling between angiogenesis and bone formation. Some cellular mole-cules, such as hypoxia inducible factor-1, vascular endothelial growth factor-A, platelet derived growth factor-BB, and slit guidance ligand3, are involved in regulating the formation of Type H vessels. Meanwhile, drugs therapy, physical therapy, and metastatic tumors can also af-fect Type H vessels. In this paper, the molecular mechanism and influencing factors of Type H vessels formation are reviewed based on theliteratures in recent years, to provide a new idea for the diagnosis and treatment of bone diseases such as fracture nonunion and abnormalbone metabolism.