Limb salvage surgery is more and more popularly used to treat malignant tumors of bone, in order to preserve limb function as much as possible. The bone defect secondary to tumor resection is usually reconstructed by prostheses or bioactive materials. In recent years, replantation of liquid nitrogen treated tumor-bearing bone has become a widely used biological reconstruction technique due to its advantag- es of simple operation, complete inactivation and high bone healing rate. At present, the technology is widely applied in Japan and Europe and America, while seldomly used in China. This article reviews the progress of bone defect reconstruction by replantation of liquid-nitrogen treated tumor-bearing bone in limb salvage surgeries for bone malignant tumors.