[Objective] To evaluate the clinical outcomes of percutaneous transforaminal endoscopic discectomy (PTED) combined with platelet-rich plasma (PRP) for discogenic low back pain (DLBP). [Methods] A total of 36 patients with DLBP were randomly divided into PRP group and non-PRP group with 18 cases in each group. The PRP group was treated with PTED combined with intradiscal injec- tion of PRP, while the non-PRP group received PTED only. The perioperative, follow-up and imaging documents were compared between the two groups. [Results] All patients in both groups had corresponding surgical procedures performed smoothly without significant differ- ences in terms of operation time, intraoperative fluoroscopy times, intraoperative blood loss and hospital stay between the two groups (P＜ 0.05), without serious adverse reactions and complications in both groups. All of them were followed up for more than 12 months, and the PRP group resumed full weight-bearing activity significantly earlier than the non-PRP group (P＜0.05). The VAS score for pain and ODI score significantly decreased (P＜0.05), while JOA score significantly increased in both groups over time (P＜0.05), which was not significant- ly different between the two groups before surgery and 3 months after surgery (P＞0.05), while in the PRP group proved significantly superi- or to those in the non-PRP group at 12 months postoperatively (P＜0.05). With respect of imaging, the PRP group also proved significantly superior to the non-PRP group in terms of the disc height and Pfirrmann grades of involved intervertebral space 12 months postoperatively (P＜0.05). [Conclusion] PTED combined with PRP is a safe and effective method for the treatment of DLBP, which can effectively relieve pain and might delay intervertebral disc degeneration to a certain extent.