Abstract: [Objective]The method of Mendelian randomization (MR) analysis was used to explore the causal relationship between overweight and the risk of hip osteoarthritis, in order to provide a theoretical basis for clinical prevention and treatment. [Method]: The public data of Genome-wide association study (GWAS) were used to carry out the study. Overweight was used as the exposure factor and hip osteoarthritis was the outcome factor. Instrumental variables （IV）related to overweight were extracted. The MR analysis method is mainly based on the inverse-variance weighted (IVW) method, and uses the MR-Egger method, the weighted median method (WME), the weighted model method (WM), and simple public methods.The simple mode (SM) method is used to supplement the verification of experimental results. Heterogeneity testing, sensitivity analysis, and pleiotropy analysis were performed on the experimental results. [Results]: IVW results showed that overweight was positively correlated with hip osteoarthritis (OR=1.72, 95% CI: 1.32-2.25; P=6.23942E-05＜0.01); MR-Egger analysis results suggested that this There is no pleiotropic effect in the study (P=0.503); Cochran's Q test result P=0.540, the difference is not statistically significant, indicating that there is no heterogeneity in the results of this study; the leave-one-out method detection analysis sequentially eliminates each for MR The analyzed single nucleotide polymorphisms (SNP) showed that a single SNP cannot significantly affect the overall effectiveness, indicating that the results of this study are stable and reliable. [Conclusion]: There is a causal relationship between overweight and hip osteoarthritis.