[Objective] To evaluate the clinical outcomes of minimally invasive decompression and interspinous dynamic stabilization for lumbar degenerative diseases. [Methods] A retrospective study was conducted on 42 patients who received microdiscectomy and Intra- SPINE implantation through minimally invasive Quadrant channel under general anesthesia for lumbar degenerative diseases from January 2015 to October 2017. The perioperative, follow-up and radiographic documents were evaluated. [Results] All patients had operation per- formed successfully with operation time of (76.4±16.8) minutes, and blood loss of (59.1±14.5) ml, and were followed up for more than 3 years. The VAS and ODI scores significantly improved at 3 months postoperatively and the latest follow-up compared with those before operation (P＜0.05) . In addition, the excellent and good rate of clinical outcomes were marked as 95.2% based on the MacNab’s criteria at the latest fol- low-up. In terms of radiographic assessment, the intervertebral disc height (DH) and intervertebral foraminal height (FH) significantly in- creased postoperatively compared with those before operation (P＜0.05) . During the follow-up, only 1 case of them developed adjacent seg- ment degeneration, without other complications. [Conclusion] The minimally invasive decompression and interspinous dynamic stabiliza- tion does achieve satisfactory clinical outcomes in the treatment of lumbar degenerative diseases.