[Objective] To introduce the preoperative design, surgical technique and preliminary clinical outcome of oblique single-cut rotation osteotomy for correction of multiplanar deformity of the femoral shaft. [Methods] A patient received abovementioned surgical treat- ment for malunion of femoral shaft fracture. Preoperative design was conducted to determine the osteotomy angle and rotation angle by com- puter, and then the operation was simulated on Mimics software, and the osteotomy guider was made by 3D printing. A longitudinal incision was made on the lateral side of the femur to expose the malunion part of the femur. The osteotomy guider was placed, and the osteotomy and rotation of the bone ends were completed according to the preoperative design, subsequently, an interlocking intramedullary nail was used to fix the osteotomy in corrected alignment with bone autograft harvesting from the iliac create around the osteotomy site. [Results] The opera- tion was performed smoothly without adverse reaction and complications. After 6 months of follow-up, the patient had no longer limping, and no pain in the knee. The CT images confirmed that the osteotomized site healed completely. [Conclusion] This oblique single-cut rotation osteotomy is feasible to correct the angulations in the coronal and sagittal planes and rotational deformities in transverse plane of the femur si- multaneously, with satisfactory short-term clinical outcome.