[Objective] To introduce the surgical technique and preliminary clinical outcomes of total resection of schwannoma in lum- bar interforaminal area under a channel through Wiltse intermuscular space. [Methods] Two patients were treated by the abovementioned operation for lumbar interforaminal schwannoma. After location of the surgical approach and working channel according to the preoperative images, a working channel 14 mm in diameter was inserted through Wiltes muscle space to reach the outer surface of the laminae. The later- al laminae were partially resected, and the ligamentum yellow was removed, the responsible nerve roots and tumor membranous structures were fully exposed, the tumor envelope was cut longitudinally along the long axis of the tumor, and the tumor was totally excised along the boundary membrane. [Results] Both patients underwent complete tumor resection in one stage smoothly, got symptoms relief completely af- ter surgery, and resumed ambulation the next day. During the follow-up lasted for 17 months, no tumor recurrence or long-term surgical complications were found. [Conclusion] The surgical procedure by a channel through Wiltse intermuscular space does completely remove the lumbar interforaminal schwannoma in one stage, avoid postoperative spinal instability and paravertebral soft tissue injury.