[Objective] To investigate the clinical effect of 3D printing assisted with Ortho-Bridge system for individualized treatment of femoral intertrochanteric fractures. [ Methods ] The clinical data of 46 cases of intertrochanteric fracture of femur treated by 3D printing-assisted with Ortho-Bridge system from January 2017 to September 2021 were analyzed retrospectively. The clinical and imaging consequences were evaluated.[ Results ] All patients were operated successfully. The mean operation time was (78±16) min, the amount of bleeding during operation was (210±113) ml, and the hospitalization stay was (13±5) days. 2 cases had heterotopic ossification, but it did not affect the motion of the joint, 2 cases had fat liquefaction and were cured after dressing change, 1 case had superficial infection and was cured after VSD drainage. The follow-up period lasted for more than 12 months.Compared with those before operation,the pain VAS score was significantly decreased at 3 months and the last follow-up (P<0.05) , while the hip Harris score and the hip extension-flexion ROM were significantly increased (P<0.05) . Radiographically, the fracture alignment was significantly improved after surgery compared to before surgery (P<0.05)， the neck-shaft angle significantly improved postoperatively (P<0.05) ,bony union of the fractures was observed in all patients.[ Conclusion ] 3D printing combined with Ortho-Bridge system is an alternative method for the treatment of intertrochanteric fracture of femur.