Spinal cord injury (SCI) is traumatic central nervous system damage resulting in a motor and sensory dysfunction that usually causes a severe and permanent paralysis. Due to the characteristics of high disability rate and high fatality rate, it causes huge economic burden to patients and society. Hair follicle-associated-pluripotent stem cells (HAPSCs) derived from Bugle area of hair follicle, these cells have multiple differentiation potential and express specific markers of embryonic neural crest cells, which is a strong candidate for cell-based therapy of SCI. The Combination strategies of cells, drug and tissue engineering can enhance its therapeutic effect. This stem cell can be a prospective cell for transplantation therapy after spinal cord injury which should be worthy of further exploration in future experiments. In this paper, the sources, isolation methods, and research progress of HAPSCs in spinal cord injury were reviewed, aiming to clarify the current research status of HAPSCs and the future research hotpots in the predicted period.