[Objective] To explore the factors related to kinesiophobia after total knee arthroplasty. [Methods] A total of 205 patients who underwent total knee arthroplasty in our hospital from January 2020 to December 2021 were enrolled in this study. The motion status was evaluated by the Tampa Scale of Kinesiophobia (TSK) score, and TSK＞37 was identified as kinesiophobia. The patients were divided in- to two groups based on whether kinesiophobia happened for univariate comparison. In addition, Pearson or Spearman correlation analysis and multiple stepwise regression analysis were performed between TSK score and clinical parameters. [Results] Among 205 patients, 36 pa- tients were diagnosed of kinesiophobia, with an incidence of 17.6% . As consequence of univariate comparison, the kinesiophobia group proved significantly greater than the non- kinesiophobia group in terms of duration of preoperative pain, preoperative VAS score, the propor- tion of revision surgery and the proportion of one-stage bilateral replacement (P＜0.05) . However, the former proved significantly lower than the latter in terms of education level, preoperative HSS score, preoperative KSS clinical score and functional score, K-SES score and social support score (P＜0.05) . Regarding Pearson or Spearman correlation analysis, the education level, preoperative HSS score, KSS clinical score, K-SES score and social support score were negatively correlated with TSK score (P＜0.05) , whereas the preoperative VAS score and pain duration were positively correlated with TSK score (P＜0.05) . In term of multiple stepwise regression analysis, the longer preoperative pain duration and lower social support score were the main factors related to the occurrence of kinesiophobia. [Conclusion] Long duration of preoperative pain is the main risk factor for the occurrence of kinesiophobia after total knee arthroplasty, while high social support score is a protective factor for reducing the occurrence of kinesiophobia.