Abstract:[Objective] This study aims to utilize Mimics software to calculate the cement dispersal rate following Percutaneous Vertebroplasty (PVP) and explore the significance of assessing dispersal rates after PVP. [Methods]A retrospective analysis of PVP patients from March 2021 to December 2022 was conducted. Based on cement dispersal rates, 40 patients were randomly selected for the low dispersal rate group (≤10%), moderate dispersal rate group (10% < x < 20%), and high dispersal rate group (≥20%).[Results] In the high dispersal rate group, the cement volume and dispersal rate were 7.5±1.1 ml and 22.4±1.5%, respectively, which were higher than those in the low dispersal rategroup (6.4±1.2 ml, 8.2±1.0%)and the moderate dispersal rate group(6.6±1.3 ml,14.8±2.4%) (P<0.001). The secondary fracture rate in the high dispersal rate group was 5.00%, significantly lower than the 25.00% observed in the low dispersal rate group (P<0.05). Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), anterior vertebral height, anterior vertebral height ratio, and local Cobb angle all improved significantly for all three groups (low, moderate, and high dispersal rate) at 1 day and 1 year postoperatively. At 1 year postoperatively, the high dispersal rate group showed more significant improvement in VAS, anterior vertebral height, and anterior vertebral height ratio compared to the low dispersal rate group, with statistically significant differences (P<0.05). Cement dispersal rate correlated with VAS, vertebral anterior height, and vertebral anterior height ratio at 1 year postoperatively (P<0.05), with corresponding r values of -0.333, 0.385, and 0.345. [Conclusion] The low dispersal rate group calculated by Mimics software exhibited higher secondary fracture rates and VAS scores at 1 year postoperatively. Notably, there was a significant reduction in vertebral anterior height and vertebral anterior height ratio at 1 year postoperatively.