[Objective] To investigate the effect of Transcutaneous electrical acupoint stimulation (TEAS) on early reaction secondary to Total knee arthroplasty (TKA). [Methods] A total of 91 patients with TKA for knee osteoarthritis were divided into two groups according to random number table method. 45 patients were treated with conventional treatment, and 46 patients were treated with TEAS in combination with conventional treatment. The clinical indexes and blood text indexes of of the two groups were compared. [Results] (1) The VAS score of the electrical stimulation group was significantly lower than that of the conventional group on postoperative day 7 and 14 (P<0.05);(2) The circumference of the electrical stimulation group were significantly lower than that of the conventional group on postoperative day 14 (P<0.05); (3) On postoperative day 3, 7, and 14, the range of motion of the electrical stimulation group was higher than that of the conventional group (P<0.05); (4) The PT of the electrical stimulation group was greater than that of the conventional group, and the Fib and D-dimer levels were significantly lower than those in the conventional group On postoperative day 7 (P<0.05) ;(5) There was no significant difference in adverse events between the two groups. [Conclusion] TEAS can effectively relieve early reaction after TKA and promote postoperative recovery.