With the development of bone tissue engineering, bone repair materials such as 3D printed polymer materials and biocompatible scaffolders have become a research hotspot in the restoration of bone defects. Among them, poly(lactic acid-co-glycolic acid) (PLGA) has good plasticity, biocompatibility and degradability. It is widely used in the research of bone defect repair materials and is an ideal material for bone defect repair. However, its application in repairing bone defects is limited by its poor mechanical properties, lack of osteogenic properties, weak acidity of local microenvironment after degradation, etc. Therefore, it is particularly important to compound it with different materials for modification and modification. Based on the physicochemical properties and degradation mechanism of PLGA, this paper reviews the research on its composite with drugs, biomolecules, inorganic materials and organic materials, providing reference and theoretical support for the future clinical application of this material.