Background: Deep vein thrombosis (DVT) is part of the common complications after lower limb joint arthroplasty. Accelerated rehabilitation and thrombus prevention and treatment strategies are compatible to a certain extent. Accelerated rehabilitation has been developed rapidly in our country in recent years. However, there have been few reports on sample studies on thrombosis after lower limb joint arthroplasty combined with accelerated rehabilitation and thrombus prevention and treatment in China. Objective: To investigate the occurrence and risk factors of deep vein thrombosis (DVT) after joint replacement of lower extremity under accelerated rehabilitation. Methods: founded on the Phoenix electronic medical record system, patients who underwent lower limb joint replacement in Director Shen's group in our hospital from December 2021 to December 2022 were retrospectively selected as the study objects. A total of 330 patients were included according to the standard of inventory. According to the results of postoperative deep vein Doppler ultrasonography, the patients were divided into thrombus group (n=46) and non-thrombus group (n=284). Univariate analysis was used to compare the differences in various indicators between the two groups. Indicators with statistical significance and those traditionally regarded as having an impact on thrombosis were included in binary logistic regression analysis to explore independent risk factors. Results: After operation, 46 patients developed deep vein thrombosis of lower extremity, 41 cases of intramuscular vein thrombosis and 10 cases of other deep vein thrombosis, a total of 51 cases. Single vein was involved in 41 cases, and double vein was involved in 5 cases, including peroneal vein + intramuscular vein in 2 cases, popliteal vein + intramuscular vein in 1 case, popliteal vein + peroneal vein in 1 case, and bilateral posterior tibial vein in 1 case. The overall incidence of thrombosis was 13.9%, the incidence of intramuscular venous thrombosis was 11.5%, and the overall incidence of other deep venous thrombosis was 2.4%. Univariate analysis showed statistically significant differences in gender composition, age, history of cardiovascular and cerebrovascular diseases, C-reactive protein before surgery, C-reactive protein on the first day after surgery, type of surgery, disease diagnosis and other indicators. Age, drinking history and preoperative D-dimer are separate risk factors for thrombosis after lower limb joint replacement. Conclusion: The results showed as is : 7In the case of accelerated rehabilitation combined with thrombosis prevention and treatment strategy, the incidence of lower extremity deep vein thrombosis was low except for intramuscular vein thrombosis. Age, alcohol consumption history, and preoperative D-dimer are independent risk factors for thrombosis after lower limb joint replacement, so clinicians should focus on patients with such conditions and improve their preoperative risk .