[Objective] To investigate the clinical outcomes of pedicle screws and laminar screw (the double- stable construct) com- bined with isthmus bone autografting for symptomatic lumbar spondylolysis in adolescents. [Methods] A retrospective study was performed on 33 adolescent patients who received abovesaid surgical procedures for symptomatic lumbar spondylolysis in our hospital from January 2019 to December 2021. Clinical and imaging data were evaluated. [Results] All patients had operation performed successfully without seri- ous complications. Among the 9 patients with Grade I spondylolisthesis before surgery, 8 patients were confirmed to have achieved anatomic reduction under fluoroscopy, with a reduction rate of 88.9%. With time of follow-up lasted for more than 12 months, VAS and ODI scores de- creased significantly (P＜0.05) . In terms of imaging, the bony healing time of isthmus ranged from 3 months to 12 months. At the last followup, all the patients got isthmic bony healing except 2 patients, with healing rate of bone grafting of 93.9%, whereas with no loosening and fracture of the implants, nor degeneration of adjacent segments. [Conclusion] This double-stable construct fixation combined with isthmic bone grafting has the advantages of short operation time, less complications, fast recovery and high isthmus healing rate for symptomatic lum- bar spondylolysis in adolescent.