Glucocorticoid (GC) has been widely used in the treatment of internal diseases. However, glucocorticoid-induced osteoporo- sis (GIOP) , one of GC adverse effects, is still a serious clinical problem. Currently, the mechanism of GIOP remains unclear, but recent stud- ies show that it might be closely related to cell senescence caused by stress and other factors, in other word, cell senescence may be involving pathogenesis of GIOP. The glucocorticoid induces the senescence of bone tissue cells, and then the senescent cells secrete senescence-asso- ciated secreted phenotype (SASP) by paracrine to produce the cascade amplification reaction of cell senescence and finally form GIOP. This article reviews the relationship between cell senescence and GIOP, related mechanisms and targeted blocking measures.