[Objective] To explore the effect of anterior cervical discectomy and fusion (ACDF) on radiographic parameters of the cervi- cal spine and the correlation between imaging parameters and clinical scores. [Methods] A retrospective study was conducted on 128 pa- tients who received ACDF for cervical degenerative diseases (CDD) in our hospital from April 2019 to April 2021. The correlation between clinical score and imaging measurement was analyzed. [Results] All patients had ACDF performed successfully without serious complica- tions, and followed up for 12~20 months with an average of (14.5±1.9) months. The JOA score increased significantly (P＜0.05) , while the NDI and VAS scores decreased significantly over time (P＜0.05) . In terms of radiographic measurements, the C₁ inclination angle remained unchanged over time (P＞0.05) , whereas the C₂ inclination angle significantly reduced at 1 year after surgery (P＜0.05) , the upper cervical curvature significantly reduced at 1 year after operation compared with that before surgery (P＜0.05) , and the lower cervical curvature tended to first rise and then decreased with statistically significant differences over time (P＜0.05) . As results of correlation analysis, preoperative JOA score was negatively correlated with the C₁ inclination angle (P＜0.05) , additionally, the NDI score was positively correlated with C₂ in- clination angle (P＜0.05) . At 1 year postoperatively, the JOA score proved still negatively correlated with the C₁ inclination angle (P＜0.05) , whereas NDI score was positively correlated with C₂ inclination angle (P＜0.05) . However, no correlation was found between other clinical and radiological parameters (P＞0.05) . [Conclusion] The ACDF does improve cervical function and quality of life of the patients, and imag- ing parameters might reflect clinical outcomes to a certain extent.