椎间孔镜治疗腰椎间盘突出症术后复发临床预测模型的建立和验证
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作者单位:

1.济宁医学院附属医院;2.济宁医学院临床医学院

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基金项目:

山东省中医药科技项目,济宁市重点研发计划


Establishment and verification of clinical prediction model for postoperative recurrence of lumbar disc herniation treated by intervertebral foramen mirror
Author:
Affiliation:

1.Affiliated Hospital of Jining Medical University;2.Clinical Medical College of Jining Medical University

Fund Project:

Shandong Province Traditional Chinese Medicine Science and Technology Project,Jining key research and development plan

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    摘要:

    目的:建立并验证一种椎间孔镜治疗腰椎间盘突出症术后复发的临床预测模型。 方法:回顾性收集我院脊柱微创中心2017年1月至2020年1月接受椎间孔镜手术治疗的腰椎间盘突出症患者,采集患者临床特征和影像学数据,按6:4的比例分为训练集和验证集,并根据是否出现复发进一步分为复发组和非复发组。将各项相关指标依次进行单因素和多因素Logistic回归分析,筛选出独立影响因素并构建临床预测模型。采用受试者工作特征(ROC)曲线下面积(AUC)、校准曲线和决策曲线分析(DCA)评估模型的区分度、校准度及临床影响力。 结果:286例患者被纳入本研究,Logistic回归分析得出Modic改变,椎间隙活动度,病程和BMI为术后复发独立危险因素,并构建列线图预测模型。经验证,训练集ROC曲线下面积0.748(95%CI:0.490-0.897),验证集ROC曲线下面积0.767(95%CI:0.778-0.667);Calibration校准曲线和Hosmer-Lemeshow检验显示预测概率为5%~70%时,模型预测曲线和实际曲线走势较为接近;DCA曲线分析表明,训练集风险阈值在 5%~ 80%之间以及验证集风险阈值在5%~55%之间时,该模型可产生较大净获益。 结论:本研究基于Modic改变,椎间隙活动度,病程和BMI构建了椎间孔镜治疗腰椎间盘突出症术后复发的列线图预测模型,经验证显示了良好的预测性能,有助于辅助临床医生判断椎间盘突出的术后复发风险。

    Abstract:

    Objective: To establish and validate a clinical predictive model for the risk of recurrent lumbar disk herniation (rLDH) after percutaneous endoscopic lumbar discectomy (PELD). Methods: Patients with lumbar disc herniation(LDH) who received PELD were retrospectively collected from January 2017 to January 2020 in Minimally Invasive Spine Surgery Center, Affiliated Hospital of Jining Medical University. Basic clinical features and imaging data were collected, eligible patients were classified as the training set and the validation set at a 6:4 ratio,respectively,and each group was further divided into recurrent group and non-recurrent group. On the basis of univariate and multivariate Logistic regression, the independent risk factors were screen out and the clinical prediction model was constructed. The area under curve(AUC) of the receiver operating characteristic(ROC),calibration curve,decision curve analysis (DCA),were used to evaluate the discrimination,calibration,and clinical impact of the model respectively. Results: A total of 286 patients were enrolled in this study. Logistic regression analysis showed that Modic changes, the range of motion, course of disease and BMI index were the independent risk factors for postoperative recurrence, and a nomogram was successfully constructed. It was verified that the area under ROC curve of the training set was 0.748 (95%CI: 0.490-0.897), and the area under ROC curve of the verification set was 0.767 (95%CI: 0.778-0.667). Calibration curve and Hosmer-Lemeshow test show that the trend of model prediction curve is close to the actual curve when the prediction probability is 5%~70%. When the risk threshold of the training set is between 5% and 80% and the risk threshold of the verification set is between 5% and 55%, the model can produce a large net benefit. Conclusions: The prediction model based on Modic changes of lumbar intervertebral disc, the range of motion, course of disease and BMI index showed the great predictive efficacy, which can help clinicians to assess the risk of rLDH.

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  • 收稿日期:2023-04-11
  • 最后修改日期:2023-04-11
  • 录用日期:2023-10-27
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