[OBJECTIVE] To study the efficacy of Extracorporeal Shock Wave Therapy (ESWT) with different wave sources in the treatment of deep, deeper and superficial bone nonunion and to investigate the influencing factors. [METHODS] Eighty-seven patients were collected from November 2011 to September 2022. The patients were divided into 32 cases of deeper bone discontinuity, including 32 cases of femur; 47 cases of deep bone discontinuity, including 10 cases of humerus, 18 cases of tibia-fibula, and 19 cases of ulnar radius; and 8 cases of superficial bone discontinuity, including 1 case of internal and external ankle, 3 cases of clavicle, and 3 cases of carpal navicular. The patients were treated every other day, and every 5-6 treatments were considered as a course of treatment, with each treatment interval of 1.5-2 months, for a total of 3-5 treatments. X-ray plain films were taken at 6, 9 and 12 months after treatment in all patients to observe the fracture healing, calculate the fracture healing rate and the amount of long bone scab production, respectively, and perform statistical processing to evaluate the effect of ESWT treatment, and also analyze the relevant factors affecting the healing rate. [RESULTS] The healing rates were 68.75%, 71.87 %, and 75.00% after 6, 9, and 12 months of treatment for deep bone nonunion, respectively; 65.22%, 73.91%, and 78.26% after 6, 9, and 12 months of treatment for deeper bone nonunion, respectively; 66.67%, 77.78%, and 77.78%; the overall healing rates were 66.67%, 73.56%, and 77.01% at 6, 9, and 12 months, respectively. There was a significant increase in the healing rate and a significant increase in the amount of bone scab compared to before shock wave treatment. Age (P=0.04) and number of treatments (P=0.01) were significant influencing factors in the treatment of osseous nonunion with shock wave. [Conclusion] Personalized shock wave treatment with different wave sources according to the depth of the bone discontinuity can achieve satisfactory results. At the same time, the duration of treatment and age are important factors influencing the treatment of bone nonunion by shock wave.