[Objective] To investigate the clinical outcomes of Ilizarov technique combined with proximal tibiofibular osteotomy in the treatment of osteoarthritis of the medial compartment of the knee joint. [Methods] From April 2018 to December 2021, 10 patients with medial compartment osteoarthritis of the knee joint were treated with the above method. The osteotomy site was determined according to the full length X-ray film of both lower limbs standing position before the operation. A longitudinal incision was made about 3cm below the head of fibula, entering from the space between the peroneal long and short muscles and the gastrocnemius muscle muscle, and a 1cm fibula was removed with a two hole osteotomy device; Using the same method, amputate the tibia below the tibial tuberosity, select a suitable fixation ring based on the patient's calf diameter, install an Ilizarov external frame, and fix the distal and proximal end of the osteotomy ring with a penetrating Kirschner wire and threaded needle. Gradually adjust the external frame 7 days after surgery to correct the deformity.[Results] All patients successfully completed the operation without vascular and nerve injury during the operation. All patients continued to wear the external fixator to maintain the correction within 21 days after the operation. The time to wear the external fixator was 90～110 days, with an average of (101.85±9.50) days. The lower limb force line achieved satisfactory correction. The follow-up time was 1～3.1 years, with an average of (1.95±0.57) years. The evaluation indexes at the last follow-up were significantly different from those before operation (p<0.05). [Conclusion] The treatment of osteoarthritis of the medial compartment of the knee joint with proximal tibiofibular osteotomy combined with circular external frame is satisfactory.