Blood vessels in bone tissue play an important role in bone growth, development, remodeling and injury repair. Type H vessels are a subtype of bone vessels with high expression of CD31 and Emcn, which have significant anatomical characteristics and age-dependent decline characteristics, and are deeply involved in the coupling between angiogenesis and bone formation. Some cellular molecules, such as hypoxia inducible factor-1, vascular endothelial growth factor-A, platelet derived growth factor-BB, and slit guidance ligand 3, are involved in regulating the formation of Type H vessels. Meanwhile, drugs therapy, physical therapy, and metastatic tumors can also affect Type H vessels. In this paper, the molecular mechanism and influencing factors of Type H vessels formation are summarized by reviewing the literature in recent years, in order to provide new thinking for the diagnosis and treatment of bone diseases such as fracture nonunion and abnormal bone metabolism.