Steroid-induced osteonecrosis（SANFH） of the femoral head is a disabling and refractory orthopedic disease characterized by bone cell ischemia、necrosis、bone trabecular fracture，clinical manifestations of pain、femoral head collapse and joint dysfunction. Its pathogenes is complex，often manifested by the combination or cross action of multiple pathways. In this paper, the pathogenesis of SANFH and its related signaling pathways were briefly reviewed, which will provide help for further understanding of the pathogenesis and prevention of SANFH.