Abstract: [Objective] To compare the clinical effect of multiple ligament reconstruction under arthroscopy with tourniquet or non-tourniquet in the treatment of KD-Ⅲ-M knee dislocation. [Methods] A total of 27 patients with knee dislocation combined with multiple ligament injury admitted from January 2017 to January 2022 were randomly grouped using a random number table, including 13 patients in the tourniquet group, who were operated under the tourniquet in the whole process.In the non-tourniquet group, 14 cases were operated without tourniquet.The perioperative data and follow-up results were compared between the two groups.[Results] Both groups successfully completed the operation, and there were no significant differences in the operation time, intraoperative blood loss , the time to get out of bed postoperative and postoperative hospital days between the two groups (P >0.05), while postoperative drainage in the non-tourniquet group was less than that in the tourniquet group [(35.6±2.7)ml vs (72.2±3.3)ml, P<0001] .VAS scores in the non-tourniquet group were lower than those in the tourniquet group at the first week after surgery (P<0.05), but there was no significant difference between the two groups at three months and the last follow-up (P >0.05).In terms of Lysholm and IKDC functional scores, there was no significant difference between the two groups at the time node of postoperative follow-up (P>0.05).[Conclusion] The effect of arthroscopic multiligament reconstruction in the treatment of KD-Ⅲ-M knee dislocation is satisfactory, and the non-tourniquet operation has the advantages of less drainage and less early pain.