Abstract: [Objective]: To investigate the efficacy of tibia transverse transport（TTT）in the treatment of severe diabetic foot complicated with sepsis/septic shock. [Methods] Patients undergoing TTT for severe diabetic foot complicated with sepsis/septic shock in our hospital from April 2015 to August 2020 were retrospectively reviewed, They were divided into the traditional treatment group (n = 32) and TTT group (n = 45) according to the treatments. The results of clinical and auxiliary examination were compared between the two groups. [Results] Compared with the traditional treatment group, the healing rate of the TTT group was significantly increased and the amputation rate，in-hospital mortality, sepsis or septic shock-related mortality and post-amputation mortality during follow-up period, and total mortality were significantly decreased (P<0.05). Compared with preoperatively, white blood cell (WBC) count, procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and Interleukin 6 (IL-6) in both groups significantly decreased postoperatively(P<0.05); WBC counts, PCT, CRP, ESR, and IL6 in the TTT group were significantly lower than those in the traditional treatment group postoperatively (P < 0.05). The postoperative vascular imaging of the foot in the TTT group was significantly better than the traditional treatment group and than preoperatively (P<0.05), and there was no change between preoperative and postoperative vascular imaging in the traditional treatment group (P>0.05). [Conclusion] In the treatment of severe diabetic foot complicated with sepsis/septic shock, and significantly decreased the amputation rate，TTT significantly increased the healing rate, in-hospital mortality, the mortality during follow-up period, and the overall mortality. There were no obvious complications during the operation. TTT is an effective treatment for severe diabetic foot complicated with sepsis/septic shock.