[Objective] To observe the effects of alendronate (AL) and teriparatide (TPTD) on scoliosis progression in bipedal mice. [Methods] Forty-five 4-week-old female C57BL/6J mice received bilateral forelimb amputation to establish a scoliosis model of bipedal mice. The animals were randomly divided into 3 groups with 15 mice in each group, including the control group, AL group and TPTD group, which were given normal saline, AL and TPTD respectively for 12 weeks. The imaging check and bone mineral density (BMD) assay were conducted. [Results] The Cobb angle increased significantly over time in all the 3 groups (P＜0.05) . At 8 and 12 weeks after amputation, the Cobb angle of scoliosis was ranked in descending order of control group ＞AL group ＞TPTD group with statistically significant overall dif- ference (P＞0.05) , which in the control group was significantly higher than that of AL group and TPTD group (P＜0.05) , whereas there was no significant difference between AL group and TPTD group (P＞0.05) . In addition, the BMD significantly increased over time in all three groups (P＜0.05) , which ranked from low to high at 4, 8 and 12 weeks after amputation were as follows: control group 0.05) . [Conclusion] Early administration of AL and TPTD in bipedal mice scoliosis model can effectively reduce Cobb angle and increase spinal BMD in growing mice.