[Objective] To explore the clinical outcomes of computer-aided design and computer-aided manufacture (CAD/CAM) or- thoses for correction of adolescent idiopathic scoliosis (AIS) . [Methods] From January 2018 to December 2019, a total of 62 patients who suffered from AIS with scoliotic Cobb angle of 25°~50° were randomly divided into two groups. Among them, 31 patients were treated with CAM orthoses, while the other 31 patients were treated with plaster mold manufactured orthoses. The clinical and imaging data were com- pared between the two groups. [Results] Of the 62 patients, 60 patients were followed up for (24.90±4.26) months on an average. No compli- cations such as skin abrasion and dyspnea occurred in any patients during the wearing period of orthosis. The sitting height and SF- 36 scores increased significantly (P＜0.05) . The body height increased in both groups, but the difference in CAM group was statistically signifi- cant (P＜0.05) , while not statistically significant in plaster group (P＞0.05) . At any corresponding time points, there were no significant dif- ferences in height, sitting height and vertical offset between the two groups (P＞0.05) . However, the CAM group had significantly better SF36 score than the plaster group at 1 year after treatment and the latest follow-up (P＜0.05) . Radiographically, the scoliotic Cobb angle de- creased significantly over time in both groups (P＜0.05) . At any corresponding time points, there were no significant differences in Cobb an- gle, C7-CSVL and AVT between the two groups (P＞0.05) . [Conclusion] Both CAM and plaster mold manufactured orthoses are effective treatments for correction of adolescent idiopathic scoliosis. By comparison, the CAM orthoses are considerably superior to the plaster mold manufactured orthoses in term of fitness to patients.