[Objective] To observe the long-term kinematic consequences, especially variation of the center of rotation (COR) of the in- volved segment, of single-segment Bryan cervical disc replacement (CDR) . [Methods] A retrospective study was conducted on 38 patients who received single-segment Bryan CDR in our hospital from January 2010 to March 2013, and had range of motion (ROM) at the affected segment ＞ 5° at the latest follow-up. Clinical and radiographic documents were analyzed. [Results] All the 38 patients had operation per- formed successfully without serious complications. The follow-up period lasted for 84 to 118 months, with a mean of (93.97±9.67) months. The symptoms related to cervical spondylosis were significantly improved at the latest follow-up. The JOA score significantly increased (P＜ 0.05) , whereas the NDI score and VAS scores for neck pain and upper limb pain significantly decreased postoperatively compared with those preoperatively (P＜0.05) . By the time of latest follow-up, no exacerbation of symptoms, readmission, or revision surgery had occurred in anyone of the patients. Radiographically, overall cervical curvature and involved segmental curvature significantly increased (P＜0.05) , whereas the overall ROM, involved segmental ROM, upper adjacent ROM and lower adjacent ROM, COR-X and COR-Y remained un- changed at the latest follow-up compared with those before operation (P＞0.05) . As correlation analysis, the COR-Y was significantly nega- tively correlated with the ROM (P＜0.05) , and the translational distance of the involved segment at the latest follow-up (P＜0.05) . In addi- tion, the ROM was significantly positively correlated with translational distance of the same segment (r=0.772, P＜0.05) . The COR-Y had no significant correlation with other clinical and imaging items (P＞0.05) , while COR-X had no correlation with any parameters (P＞0.05) . [Conclusion] The clinical and radiographic results of single-segment Bryan CDR do still be satisfactory more than 7 years after operation. The relationships between COR-Y, translational displacement and ROM of the involved segment at the last follow-up is similar to that of normal cervical segment, which is conductive to remaining motion in physiologic manner.