[Objective] To evaluate the clinical efficacy of spinal fusion hybridized with dynamic fixation for multi-level lumbar degen- erative diseases. [Methods] From August 2017 to March 2019, a total 56 patients underwent spinal fusion hybridized with dynamic fixation for multi-level lumbar degenerative diseases in our department. The clinical and imaging documents were observed and analyzed. [Results] All patients had operation performed successfully with accurate screw placement and no iatrogenic injuries to nerve roots or cauda equina. Of them, 31 patients had lesions from L3 to L5, including 26 patients with L4/5 fusion and 5 patients with L3/4 fusion, while the remaining 25 patients were from L4 to S1, including 21 patients with L4/5 fusion and 4 patients with L5~S1 fusion. At the latest follow-up lasted for (23.23± 7.34) months on an average, the VAS scores for low back pain and leg pain, as well as ODI scores significantly decreased (P＜0.05) , while JOA score significantly increased compared with those preoperatively (P＜0.05) . In term of imaging evaluation, the intervertebral space height in the fused segment significantly increased (P＜0.05) , while the ROM disappeared at the latest follow-up compared with those be- fore operation. By contrast, in the non-fusion segment intervertebral space height remained unchanged (P＞0.05) , with significantly de- creased ROM (P＜0.05) . No loosening and displacement of the implants were noted in anyone of them until the latest follow-up. [Conclusion] The spinal fusion hybridized with dynamic fixation does achieve satisfactory clinical consequences for multi-level lumbar degenera- tive diseases.