Objective To investigate the clinical efficacy of Delta large channel endoscopic surgery for lumbar disc herniation. Methods This study retrospectively analyzed the data of 73 patients who underwent Delta large channel endoscopic surgery for lumbar disc herniation from January 2020 to October 2021. Demographic characteristics, perioperative indicators, complications, and imaging features of the patients were collected. At each follow-up time point, clinical outcomes were quantified using VAS and ODI scores, and final Macnab criteria were used to evaluate surgical satisfaction. Results The patients in this study had a significant decrease in low back pain VAS scores, leg pain VAS scores and ODI scores at 12 months postoperatively compared to preoperatively (p<0.001). At the final follow-up, there was no significant difference in the anterior lumbar convexity angle postoperatively compared to preoperatively (39.7±17.2 vs. 41.7±14.3, p=0.106), and the disc height index was significantly higher postoperatively compared to preoperatively (26.6±4.9 vs. 28.2±5.2, p<0.001). The excellent rate by MacNab criteria at the final follow-up was 82.19% (60/73). Conclusion The efficacy of Delta's large channel endoscopy for lumbar disc herniation is generally satisfactory and can be used as a minimally invasive procedure for the clinical treatment of lumbar disc herniation.