Objective: To explore the short-term clinical effect of patients with AO-C distal radius fracture treated by Henry approach by suturing pronator muscle. Methods: From January 2018 to August 2019, 52 patients with AO-C distal radius fractures treated by Henry''s approach and internal fixation with titanium plate and screws were retrospectively analyzed. They were divided into two groups according to whether the pronator muscles were sutured during operation. The sutured group sutured the pronator muscles after the titanium plate and screws were satisfactory during operation, and the non-sutured group sutured the fascia, subcutaneous tissue and skin directly after the titanium plate and screws were satisfactory during operation. The wrist joint ROM and forearm rotation range of motion (pronation and supination) were recorded and compared between the two groups at 1 month and 3 months after operation. The VAS score of pain at 1 week, 1 month and 3 months after operation and the excellent and good rate of wrist joint function at the last follow-up were recorded and compared between the two groups.Results: All the 52 patients successfully completed the operation and were followed up for at least 12 months, with an average of (13.57 2.51) months. After 1 month and 3 months follow-up, there was no significant difference in wrist joint ROM between the two groups (P>0.05). At one month''s follow-up, the forearm pronation range of the suture group (45.35±8.96) was higher than that of the non-suture group (39.64±9.51), and the pronation range of the suture group (45.84±9.75) was higher than that of the non-suture group (40.18±8.37), with statistical significance (P<0.05). After 3 months follow-up, there was no significant difference in forearm pronation and supination between the two groups (P>0.05). At one week after operation, the VAS score of the suture group (3.32±0.48) was lower than that of the suture group (5.34±1.25), and at one month after operation, the VAS score of the suture group (2.45±0.78) was lower than that of the non-suture group (3.23±0.98), with statistical significance (P < 0.05). At 3 months, there was no significant difference in VAS scores between the two groups (P>0.05). At the last follow-up, the excellent and good rate of wrist function in the suture group (90.00%) was higher than that in the non-suture group (78.00%), but the difference was not statistically significant (P>0.05). Conclusion: Using Henry''s approach to treat AO-C distal radius fracture, suturing the pronator muscle during operation can effectively relieve the short-term postoperative pain and improve the postoperative forearm rotation activity. It is suggested that the pronator muscle should be sutured as much as possible during operation.