[Objective] To investigate the early outcomes of doctor-nurse cooperated enhanced recovery after surgery (ERAS) for poste- rior lumbar instrumented fusion (PLIF) . [Methods] From January 2021 to June 2021, a total of 60 patients who underwent PLIF for degen- erative lumbar diseases were divided into two groups by random number table method. Of them, 30 patients received routine perioperative rehabilitation (the routine group) , while the other 30 patients received doctor-nurser cooperated ERAS. The clinical and psychological as- sessment data of the two groups were compared before and 1 week after operation. [Results] The ERAS group resumed walking significant- ly earlier than the routine group (P＜0.05) . The VAS and ODI scores significantly decreased, whereas JOA score significantly increased at 1 week after operation compared with those preoperatively in both groups (P＜0.05) . One week after surgery, the ODI and JOA scores in the ERAS group were significantly better than those in the routine group (P＜0.05) , but there was no significant difference in VAS scores be- tween the two groups (P＞0.05) . Both SDS and SAS scores significantly decreased 1 week after surgery compared with those before opera- tion in the two groups (P＜0.05) . One week after operation, the ERAS group proved significantly superior to the routine group in terms of SDS and SAS scores (P＜0.05) . [Conclusion] The doctor-nurse cooperated enhanced recovery after surgery does accelerate the recovery of lumbar function, and effectively relieve anxiety and depression in the perioperative period of posterior lumbar instrumented fusion.