Taurine upregulated gene 1 (TUG1) is a long non-coding RNA (lncRNA) , which involves in the occurrence and develop- ment of osteosarcoma by complex molecular mechanisms. It can promote the proliferation, invasion and metastasis, and inhibit the apopto- sis of osteosarcoma cells by inhibiting some miroRNAs (miRNAs) and regulating related signal pathways. In addition, the expression level of TUG1 is related to the prognosis of osteosarcoma, therefore, TUG1 is a potential biomarker for prognosis. In this paper, by summarizing related studies in recent years，we review the molecular mechanisms of proliferation, apoptosis, invasion and metastasis in osteosarcoma cell mediated by TUG1 and the clinical value of TUG1 in osteosarcoma.