[Objective] To investigate the correlation between symptomatic benign prostatic hyperplasia (SBPH) and periprosthetic joint infection (PJI) secondary to primary total hip arthroplasty (THA) . [Methods] A total of 133 male patients who underwent primary THA in our hospital from January 2011 to December 2018 were included in this study. According to whether PJI was confirmed during the fol- low-up, the patients were divided into two groups. Univariate comparison and binary multiple logistic regression analysis were conducted to search the factors related to PJI. [Results] All the 133 patients were followed up for more than 24 months, with an average of (5.80±1.77) years. According to the PJI diagnostic criteria of MSIS in 2013, 10 patients were confirmed as PJI during follow-up, accounting for 8.13% with a mean PJI occurrence time of (6.12±2.91) months after the primary operation, and all infected patients adopted posterolateral ap- proach. As consequence of univariate comparison, the PJI group had significantly higher ratios of comorbidity of diabetes, SBPH, postoper- ative drainage placement, postoperative urinary tract infection, as well as significantly higher BMI, postoperative drainage volume and drainage time than the non-PJI group (P＜0.05) , whereas the former had significantly lower preoperative albumin level than the latter (P＜ 0.05) . There were no significant differences between the two groups in terms of age, side, preoperative ESR, preoperative WBC, preopera- tive D-dimer, operation time, transfusion volume and anesthesia mode between the two groups (P＞0.05) . As results of logistic regression, comorbidity of SBPH (OR=3.267, P＜0.05) , comorbidity of diabetes mellitus (OR=2.482, P＜0.05) , and postoperative urinary tract infection (OR=2.542, P＜0.05) were independent risk factors for PJI. [Conclusion] SBPH is an important independent risk factor for PJI after primary THA.