[Objective] To compare clinical outcomes of percutaneous vertebroplasty (PKP) with low- viscosity bone cement in wetsand phase (WSP) versus wire- drawing phase (WDP) for osteoporotic vertebral compressive fracture (OVCF) . [Methods] From January 2018 to June 2020, a total of 146 patients with OVCF were enrolled in this study. According to the doctor-patient communication, 80 pa- tients had PKP performed with low- viscosity bone cement in WSP, whereas 66 patients received PKP with low-viscosity bone cement in WDP. The perioperative period and follow-up consequences were compared between the two groups. [Results] All the patients had opera- tion done successfully in both groups without neurovascular injury and other serious complications. There were no significant differences in operation time, intraoperative fluoroscopy times, amount of bone cement and hospitalization cost between 2 groups (P＜0.05) . However, WSP group had significantly higher excellent and good ratio of bone cement distribution than the WDP group (P＜0.05) , additionally, the former had significantly less occurrence of bone cement leakage than the latter (P＜0.05) . As time went during the follow up period lasted for (23.23±7.94) months, the VAS score in both groups decreased significantly (P＜0.05) . At 7 d, 30 d and the latest follow-up, the WSP group had significantly lower VAS score than the WDP group (P＜0.05) . [Conclusion] The PKP with low viscosity bone cement in wet-sand phase does achieve better therapeutic effect on OVCF than that in the wire-drawing phase.