[Objective] To explore the outcomes of clinical nursing for senile femoral neck fracture without surgical treatment. [Methods] From March 2016 to March 2021, a total of 70 patients who were hospitalized in our hospital for femoral neck fractures and received nonoperative treatment due to heart disease or intolerance to surgery were randomly divided into two groups by the lottery method. Of them, 35 patients were given primary care (the routine group) , while the remaining 35 patients received family care, nutritional support, pain con- trol, cardiac function nursing and monitoring, as well as rehabilitation training on basis of primary care (the comprehensive group) . The in- cidence of complications, pain, quality of life and nursing satisfaction were compared between the two groups. [Results] The complication rate was of 20.00% (7/35) in the routine group, whereas 5.71% (2/35) in the comprehensive group, which proved statistically significant (P＜ 0.05) . No death occurred in anyone of them in both groups until discharge. Compared with those at admission, VAS score significantly de- creased (P＜0.05) , while WHOQOL-BREF score significantly increased at discharge (P＜0.05) . The comprehensive group was significantly superior to the routine group in terms of VAS and WHOQOL-BREF scores at the end of interventions (P＜0.05) . At discharge, the satisfac- tion rate of patients and relatives in the comprehensive group was significantly better than that in the conventional group (P＜0.05) . [Conclusion] Comprehensive nursing intervention for senile femoral neck fracture with non-surgical treatment does reduce complications and improve the quality of life of patients.