To introduce the method and clinical effect of traction reduction assisted with intramedullary nail and plate in the treatment of tibiofibular fracture in lateral position. [Methods] 46 cases of tibiofibular fracture were treated with traction reduction in lateral bending position and intramedullary nail and plate. The patient lies on the side with knees bent, the affected limb is placed parallel to the healthy limb, Kirschner wire is drilled into the tibial plateau and calcaneus respectively, bone traction reductor is installed, traction is used to reset the fracture, and MIPPO technology is used to place metal plate for internal fixation through small incision of fibula. Take the longitudinal incision in the middle of the anterior patella of the knee, split the patellar ligament, flex the knee joint for reaming, and place the intramedullary nail. The operation time, reduction loss rate during operation, open reduction rate, fluoroscopy time during operation, intraoperative blood loss, ankle posterior foot score of American Foot and Ankle Surgery Association at the last follow-up, fracture healing time, and postoperative infection rate were observed [results] 46 patients had intraoperative blood loss (120.8 ± 8.1ml), ankle posterior foot score of the American Foot and Ankle Surgery Association at the last follow-up (92.8 ± 2.6 points), fracture healing time (24.1 ± 1.8 weeks), postoperative infection (0 cases), operation time (118.5 ± 2.0min), intraoperative reduction loss rate (2 cases, 9.1%), intraoperative open reduction rate (1 case, 4.5%), and fluoroscopy time (20.1 ± 3.2S). [Conclusion] Treatment of tibia and fibula fracture with traction reduction in lateral bending knee position and intramedullary nailing and steel plate, with fast reduction, convenient operation, convenient intraoperative fluoroscopy, reducing the incidence of intraoperative reduction loss and open reduction, and shortening the operation time.