Regulating Osteogenesis by Osteoimmune is an aroused general interest in the fieldof bone defect repair research; Regulatory T cells (Treg)are the main cells thatmediate bone immunity and closely related to glucocorticoid-induced ONFH. Afterbone tissue injuries, Treg cells are directed to the local injury sites throughCCL22/CCR4 axis regulation, get activated by STAT5/FoxP3 pathway synthesizingfactors of promoting tissue-repair, and cross-talk with MSCs regulatingosteogenesis and angiogenesis process which promote bone repair. The MiR-155/SOCS1regulatory loop regulates the activation of the STAT5/FoxP3 pathway; hormonesinhibit MiR-155 promotion on the expression of SOCS1 and inhibit the activation ofthe STAT5/FoxP3 pathway and Treg cells. Regulate Treg cells towards thehost site, MiR-155 targeted to transfect CD4+ T cells which inhibits SOCS1expression, and Activating the STAT5/FoxP3 pathway could activate Treg cells,therefore building a Treg-mediated microenvironment for osteogenesis immunity,which regulates the osteogenesis and angiogenesis of BMSCs to repairosteonecrosis, and help us to study the pathogenesis and prevention ofsteroid-induced ONFH on osteoimmunology level.