Hippo signaling pathway mediates signal transmission inside and outside cells.The pathway regulates the process of cell proliferation，differentiation and apoptosis.And role in bone metabolism，lipid metabolism and angiogenesis also can be influenced.Therefore，this pathway may be of great significance in the pathogenesis of non-traumatic femoral head necrosis.This paper mainly discusses the mechanism of Hippo pathway related protein structure and function in bone metabolism and lipid metabolism，and looks for its mechanism in NONFH，so as to provide a new clinical research target for NONFH.