Abstract:Objective Evaluation of the effects of bone marrow mesenchymal stem cells (BMSCs) versus platelet-rich plasma (PRP) on healing after rotator cuff injury . Methods From September 2019 to October 2021, 160 patients in the two groups underwent arthroscopic rotator cuff repair. 80 patients in the experimental group were treated with shoulder arthroscopy and adjuvant treatment of bone marrow mesenchymal stem cells and platelet rich plasma, while 80 patients in the control group were only treated with shoulder arthroscopy.All patients were treated with the same rehabilitation program and followed up for 1 year. The healing of tendon repair was confirmed by MRI scan. The pain and shoulder function were evaluated by visual analogue scale (VAS), shoulder range of motion (ROM) and UCLA functional scoring standard. Results The mean VAS score of the two groups improved significantly, but there was no significant difference between the two groups in the final follow-up (P = 0.747). Compared with the preoperative measurement results, the flexion, abduction and lateral external rotation of the two groups were significantly improved in the last follow-up (all P < 0.05). However, no significant difference was observed between the two groups in the final follow-up (P = 0.898, 0.524, 0.057). The UCLA scores of the two groups were significantly improved after operation (all P < 0.05), but there was no significant difference between the two groups at the final follow-up (P = 0.829).Through magnetic resonance imaging, during one-year follow-up, 66 (80%) of 80 patients in the experimental group found complete rotator cuff, while only 48 (60%) of 80 patients in the control group found complete rotator cuff (P < 0.05), and the magnetic resonance score of the experimental group was better than that of the control group (P < 0.05). Conclusions This experiment can be observed that MRI shows that compared with simple surgical treatment, increasing bone marrow mesenchymal stem cells and platelet rich plasma for adjuvant treatment significantly improves the healing results after rotator cuff injury repair and reduces the rate of re tear. The standard outcome measurement method showed that the postoperative clinical difference was not significant.