Objective: To observe the clinical effect of percutaneous transforaminal endoscopy discectomy (PTED) combined with platelet-rich plasma (PRP) in patients with discogenic low back pain (DLBP), analyse the safety and efficacy. Methods: Thirty-six patients with DLBP were randomly divided into PRP group and non-PRP group, eighteen cases in each group. The PRP group was treated with PTED combined with disc injection of PRP, the non-PRP group was treated with PTED. All the patients were evaluated before and after the treatment by VAS score, JOA score and ODI index. To reexamine lumbar MRI at 12th month after treatment, record the changes of disc height and Pfirrmann classification of responsible lumbar intervertebral disc. Results: Thirty-six patients were all followed up, there was no serious adverse reaction or complication occurred. There were significant differences in VAS score, JOA score and ODI index between pre-treatment and post-treatment in two groups (P<0.05). There were significant differences in all scores between two groups at 1th week, 12th month after the treatment (P<0.05). There was no significant difference in all scores between two groups at 3th, 6th month after the treatment (P>0.05), and the changes of disc height and Pfirrmann classification of PRP group were significantly better than that non-PRP group at 12th month after treatment (P<0.05). Conclusion: PTED combined with PRP is safe and effective minimally invasive surgery for the treatment of DLBP, it can effectively alleviate the short-term postoperative pain, and can slow down the degeneration of intervertebral disc in long-term follow-up.