Abstract:[Objective] To investigate the related factors of kinetophobia after total knee arthroplasty. [Methods] A total of 205 patients undergoing total knee arthroplasty in our hospital from January 2020 to December 2021 were enrolled by convenience sampling method. They were divided into two groups according to the occurrence of postoperative kinetophobia. The general data of the two groups were analyzed by single factor analysis, and then the correlation between potential risk factors and TSK score was discussed. Finally, multivariate stepwise regression analysis was used to determine the relationship between risk factors and the degree of kinetophobia. [Results] Among 205 total knee arthroplasty patients, 36 patients were diagnosed with kinetophobia, and the incidence of kinetophobia was 17.56%. The preoperative pain duration, preoperative VAS score, the proportion of revision surgery and the proportion of primary bilateral replacement in patients with mophobia were higher than those in the non-kinetophobia group. The educational level, preoperative HSS score, preoperative KSS clinical score and functional score, K-SES score and social support score of patients in the kinetophobia group were significantly lower than those in the non-kinetophobia group, the differences were statistically significant (P < 0.05). Correlation analysis showed that educational level, preoperative HSS score, KSS clinical score, K-SES score and social support score were negatively correlated with TSK score. The preoperative VAS score and pain duration were positively correlated with TSK score (P < 0.05). Multiple stepwise regression analysis showed that preoperative pain time and social support score were the related factors affecting the development of kinetophobia. [Conclusion] Preoperative pain duration was a risk factor for kinetophobia after total knee arthroplasty, and was positively correlated with kinetophobia degree, while social support score was a protective factor to reduce the incidence of kinetophobia and was negatively correlated with the degree of kinetophobia.