[Objective] To explore the application of trephination in the technique of anterior endoscopic cervical transcorporeal discectomy (AECTcD). [Methods] From Sep. 2018 to Sep. 2019, AECTcD was performed for 29 patients with central cervical disc herniation (CDH) and the trephine was used to create the bony channel. There were 14 males and 15 females; the average age was 54.45?10.85 years old. Visual analog scale (VAS) and Japanese Orthopedic Association score (JOA) are used to assess the clinical results; lateral radiography is conducted to measure the drilled vertebra and intervertebral disc height (IDH); MRI is used to evaluated the status of bony channel and intervertebral disc. [Results] The average operation time was 86.00?9.30min. No surgery-related complications were observed. The average follow-up periods were 29.17?3.70months. Compared with preoperative VAS score, the score postoperative 1 day decreased significantly (P<0.05). At final follow-up stage, the pain of all patients nearly disappeared; the improvement of JOA score was significant compared with preoperative score (P<0.05), with an average improvement rate of (90.88?8.72) %; the postoperative IDH was decreased significantly compared with those of preoperative (P<0.05); the changes of drilled vertebra height did not differ significantly (P>0.05); no recurrence at operated segment was observed and the bony channel was disappeared almost on MRI images. [Conclusions] The successful application of trephine strengthens the controllability for the establishment bony channels and improves the accuracy of bony channel, which provides a safe, effective and simple method of channel establishment for AECTcD.