Abstract:Glucocorticoid (GC) has been widely used in the treatment of internal diseases. However, glucocorticoid-induced osteoporosis (GIOP), one of its side effects, are still a serious clinical problem. Currently, the mechanism of GIOP is still unclear, but recent studies show that it is closely related to cell senescence caused by stress and other factors. Cell senescence may be a mechanism of GIOP: First, glucocorticoid induces the senescence of bone tissue cells. And then the senescent cells secrete senescence-associated secreted phenotype (SASP) by paracrine to produce the cascade amplification reaction of cell senescence and finally form GIOP. This article reviews the relationship between cell senescence and GIOP, related mechanisms and targeted blocking measures.