Abstract:[Objective] To investigate the feasibility and clinical effect of Ilizarov technique in the treatment of infected tibial defect with clubfoot deformity. [Methods] 45 cases of infected tibial defect with clubfoot deformity were analyzed retrospectively from January 2013 to September 2020. Paley's osteomyelitis healing standard, AOFAS ankle-foot system score and complication rate were evaluated and the experience and deficiency were summarized. [Results] 45 patients were followed up. The average follow-up time was (28.6 ± 12.4) months. All patients with bone defects and osteotomies healed in one stage without recurrent infection. The average length of bone transport was (6.7 ± 3.2) cm. The average time of bone transport was (3.2 ± 1.3) months and the average time of external fixation was (20 ± 5.8) months. The average wound healing time was (36 ± 11.2) days. At the last follow-up, the score of AOFAS was (85.65 ± 10.45), which was significantly different from that before operation (29.32 ± 6.76)(p<0.05). According to Paley's criterion, bone union of all patients were excellent. According to the function, 38 patients were excellent, 4 patients were good, and 3 patients were normal. During the course of treatment, no serious complications occurred. [Conclusion] Ilizarov technique could be used to treat osteomyelitis, repair large bone defects and correct plantar flexion deformity of ankle. It has completely cured osteomyelitis, repaired the defect of bone and soft tissue, restored the length of the affected limb, and corrected the clubfoot deformity.