Secondary lesions of spinal cord injury (SCI) , such as oxidative stress and apoptosis, further aggravate the neurological im- pairment. The microRNAs (miRNAs) are a novel class of small non-coding RNAs that regulate protein production and cell function by si- lencing translation or interfering with the expression of target mRNAs. SCI alters the expression of miRNAs associated with many secondary injuries such as oxidative stress, inflammation and apoptosis. This review aims to clarify the latest research progress of miRNAs in apopto- sis and oxidative stress secondary to spinal cord injury, and to provide a reference for further research of miRNAs in spinal cord injury.