Abstract:[Objective] To evaluate the clinical outcomes of minimally invasive decompression and interlaminar dynamic stabilization for the treatment of lumbar degenerative diseases. [Methods] A retrospective study was conducted on 42 patients with lumbar degenerative diseases from January 2015 to October 2017. All patients underwent microdiscectomy and IntraSPINE implantation through minimally invasive Quadrant channel under general anesthesia. The perioperative data was recorded. The visual analog scale (VAS) of the back and leg pain, Oswestry dysfunction index (ODI), and the modified MacNab criteria were used to evaluate the clinical efficacy. The disc height (DH) and foraminal height (FH) measured on radiographs were used to evaluate the imaging efficacy. Complications during the perioperative and follow-up periods were recorded. [Results] All patients successfully completed the operation and were followed up for more than 3 years. The average operation time was (76.43±16.83) minutes, and the blood loss was (59.05±14.45)ml. The VAS and ODI scores were significantly improved after operation compared with those before operation (P<0.05), and the MacNab excellent and good rate at the last follow-up was 95.24%. In terms of radiographic assessment, the DH and FH significantly increased postoperatively compared with those before operation (P<0.05). During the follow-up, 1 case developed adjacent segment degeneration, and no other complications occurred. [Conclusion] The clinical outcomes of minimally invasive decompression and interlaminar dynamic stabilization in the treatment of lumbar degenerative diseases is satisfactory.