Abstract: [Objective] To Comparison the clinical effects of two surgical options for Bennett fracture—open reduction and fixation with locking plate vs. closed reduction and fixation Kirschner wires. [Methods] 52 patients with Bennett fracture treated in our hospital from January 2015 to January 2019 were analyzed retrospectively. According to the results of preoperative doctor-patient communication, 28 patients were treated with open reduction and fixation with locking plate (plate group) and 24 patients with closed reduction and fixation Kirschner wires (K-wire group). The perioperative period, follow-up and imaging data of the two groups were compared. [Results] all the patients in the two groups completed the operation successfully, and there was no significant difference in perioperative time, hospital stay, incision healing and complications between the two groups (P > 0.05). The number of intraoperative fluoroscopy in the plate group was better than that in the K- group, and the intraoperative blood loss in the Kirschner wire group was better than that in the plate group (P < 0.05). According to the follow-up results, there was no significant difference in the time of complete weight bearing, VAS score at 3 months and 1 year after operation, and DASH score at 1 year after operation between the two groups. However, the active activity time and DASH score 3 months after operation in the plate group were significantly better than those in the K-wire group. In terms of imaging, there was no significant difference in postoperative fracture healing time between the two groups (P > 0.05). However, the alignment of the fracture and the first carpometacarpal joint in the plate group was significantly better than that in the K-wire group (P < 0.05). [Conclusion] Both of the two methods can achieve good results in the treatment of Bennett fracture, each has its own advantages and disadvantages, but the open reduction and plate fixation is accurate and reliable, and the patients can take early functional exercise and recover the function of the affected limb more quickly after operation.